The Ligue 1 leaders head to Groupama Stadium to take on the team directly below them in the standings and, despite the 11-point gap between the sides, it is likely to be a tense encounter in the Rhone-Alpes.
Les Gones won this fixture in 2015-16, only for PSG to get their revenge last season.
With a sell-out crowd expected, Emery admits his side will need to be at the top of their game in what is likely to be a fiery atmosphere.
“Lyon are second, the stadium will be full and their team will be out to beat us,” he told reporters. “Every match we play is a special one for our opponents. We need to prepare well for the match and know exactly what we need to do on Sunday.
“Just as the one to Nantes was, this trip to Lyon will be difficult. Every side has their differences but Lyon are a great team.”
Uwe Rosler was sacked by Fleetwood following a 3-0 reverse at Doncaster which condemned Town to a seventh straight defeat in all competitions.
Cambridge interim head coach Joe Dunne was pleased with how his side adapted to beat Grimsby 3-1.
Southend manager Chris Powell led the applause for Jason Demetriou after the right-back scored twice in the 3-1 win against Portsmouth at Roots Hall.
Morecambe boss Jim Bentley was the happier manager after Gregg Wylde's 90th-minute strike earned his side a point in their 1-1 draw with Forest Green.
Manager Gareth Ainsworth described Wycombe's 2-0 win at Cheltenham as a thoroughly professional performance.
Skipper Richard Wood scored the winner just before half time as in-form Rotherham pulled off a 1-0 victory at League One leaders Shrewsbury.