Spurs will head into the match at Wembley Stadium fifth in the Premier League standings, a place and four points clear of Arsenal, and they are on an 11-game unbeaten run in all competitions.
Mauricio Pochettino’s side are also unbeaten in their last 12 home games in the top-flight, a run that stretches back to August, although they have not faced Arsenal at Wembley since they lost 1-0 in an FA Cup semi-final 25 years ago – Tony Adams grabbing the only goal of the game that day.
Tottenham could hand a debut to deadline day signing Lucas Moura following his £23million move from Paris Saint-Germain, while Toby Alderweireld, Harry Winks and Danny Rose are all in contention after returning from long-term injuries during the midweek FA Cup success against Newport.
Arsenal will head into the contest on the back of last weekend’s 5-1 demolition of Everton, although that victory came on home soil, while their form on the road has been far less impressive, as they average just a point per game on their travels this season.
The Gunners were beaten 3-1 by Swansea in their last away fixture, but they will take confidence from the fact they did beat Spurs when the two teams met at the Emirates earlier in the season, although the now departed Alexis Sanchez was one of their goalscorers that day.
Boss Arsene Wenger is currently sweating over the fitness of goalkeeper Petr Cech, who was substituted during last weekend’s victory over Everton with a calf problem.
Danny Welbeck and Nacho Monreal are expected to be fit, however, as they have recovered from injury and illness respectively.
Uwe Rosler was sacked by Fleetwood following a 3-0 reverse at Doncaster which condemned Town to a seventh straight defeat in all competitions.
Cambridge interim head coach Joe Dunne was pleased with how his side adapted to beat Grimsby 3-1.
Southend manager Chris Powell led the applause for Jason Demetriou after the right-back scored twice in the 3-1 win against Portsmouth at Roots Hall.
Morecambe boss Jim Bentley was the happier manager after Gregg Wylde's 90th-minute strike earned his side a point in their 1-1 draw with Forest Green.
Manager Gareth Ainsworth described Wycombe's 2-0 win at Cheltenham as a thoroughly professional performance.
Skipper Richard Wood scored the winner just before half time as in-form Rotherham pulled off a 1-0 victory at League One leaders Shrewsbury.