The Seagulls have slipped down the table in the second half of the season and head into the home clash just one point and three places above the drop zone following Wednesday’s draw at Southampton.
Chris Hughton drafted in Leonardo Ulloa on loan shortly before Wednesday’s transfer deadline and the Argentinean could be handed his first start since returning for a second spell, having made a cameo appearance from the bench against the Saints.
Fellow new arrival Jurgen Locadia is back in training following a hamstring injury and he is pushing towards his first inclusion after completing a move from PSV last month, but Saturday’s game will come too soon.
West Ham are unbeaten in six Premier League engagements, however, they have only won twice during that run, and they also find themselves in danger of being involved in a relegation battle.
Joao Mario made his debut in the draw with Crystal Palace on Tuesday and is expected to get the nod once again, while Jordan Hugill will be hoping to play some part after completing a deadline day switch from Preston.
David Moyes still has plenty of injuries to contend with as the likes of Pedro Obiang, Marko Arnautovic, Manuel Lanzini and Andy Carroll remain in the treatment room.
New Zealand international Winston Reid is close to making a full recovery from a groin injury and will be handed the chance to prove himself in a late fitness test.
Newly promoted Brighton will be hoping for a repeat of their performance from earlier in the season when they beat West Ham 3-0 at the London Stadium.
Uwe Rosler was sacked by Fleetwood following a 3-0 reverse at Doncaster which condemned Town to a seventh straight defeat in all competitions.
Cambridge interim head coach Joe Dunne was pleased with how his side adapted to beat Grimsby 3-1.
Southend manager Chris Powell led the applause for Jason Demetriou after the right-back scored twice in the 3-1 win against Portsmouth at Roots Hall.
Morecambe boss Jim Bentley was the happier manager after Gregg Wylde's 90th-minute strike earned his side a point in their 1-1 draw with Forest Green.
Manager Gareth Ainsworth described Wycombe's 2-0 win at Cheltenham as a thoroughly professional performance.
Skipper Richard Wood scored the winner just before half time as in-form Rotherham pulled off a 1-0 victory at League One leaders Shrewsbury.