The Ivory Coast international has undoubtedly been Palace’s key player this season but they may have to do without him for up to a month.
Zaha suffered a knee injury at the start of the season and the Eagles struggled to pick up results in his absence, however his return coincided with them climbing out of the bottom three.
The winger is understood to have sustained up his latest injury in the first half of the 1-1 draw with Newcastle but opted to continue playing for the rest of the game.
The 25-year-old was sent for a scan on Monday and is set to see a specialist on Tuesday to learn the full extent of the issue.
Palace are almost certain to be without Zaha for Saturday’s trip to Everton while they also face Tottenham and Manchester United over the next four weeks.
Uwe Rosler was sacked by Fleetwood following a 3-0 reverse at Doncaster which condemned Town to a seventh straight defeat in all competitions.
Cambridge interim head coach Joe Dunne was pleased with how his side adapted to beat Grimsby 3-1.
Southend manager Chris Powell led the applause for Jason Demetriou after the right-back scored twice in the 3-1 win against Portsmouth at Roots Hall.
Morecambe boss Jim Bentley was the happier manager after Gregg Wylde's 90th-minute strike earned his side a point in their 1-1 draw with Forest Green.
Manager Gareth Ainsworth described Wycombe's 2-0 win at Cheltenham as a thoroughly professional performance.
Skipper Richard Wood scored the winner just before half time as in-form Rotherham pulled off a 1-0 victory at League One leaders Shrewsbury.