The Sun claims Eagles boss Roy Hodgson faces a goalkeeping crisis as Wayne Hennessey is his only experienced option in that key position for a crucial part of the relegation fight.
Speroni has started 11 Premier League matches for Palace this term, the last of which was the 3-2 home defeat to Arsenal on December 28.
The 38-year-old had been on the bench since then, but was missing from the squad altogether when Palace drew 1-1 with Newcastle last weekend.
Having sustained the injury in training, further tests have shown Speroni will not be back until April.
Dion Henry, a 20-year-old keeper signed on a free transfer from Peterborough last summer, is Hodgson’s back-up option until then.
Uwe Rosler was sacked by Fleetwood following a 3-0 reverse at Doncaster which condemned Town to a seventh straight defeat in all competitions.
Cambridge interim head coach Joe Dunne was pleased with how his side adapted to beat Grimsby 3-1.
Southend manager Chris Powell led the applause for Jason Demetriou after the right-back scored twice in the 3-1 win against Portsmouth at Roots Hall.
Morecambe boss Jim Bentley was the happier manager after Gregg Wylde's 90th-minute strike earned his side a point in their 1-1 draw with Forest Green.
Manager Gareth Ainsworth described Wycombe's 2-0 win at Cheltenham as a thoroughly professional performance.
Skipper Richard Wood scored the winner just before half time as in-form Rotherham pulled off a 1-0 victory at League One leaders Shrewsbury.