The Hammers have moved up to 11th in the table off the back of two wins and three draws, but crashed out of the FA Cup to League One leaders Wigan at the weekend.
David Moyes has a huge injury list with no fewer than nine first-team stars missing – including Andy Carroll, Manuel Lanzini, Marko Arnautovic, Andre Ayew and Cheikhou Kouyate. West Ham are also without Arthur Masuaku through suspension, following his sending off at Wigan.
Moyes though could hand a debut to new signing Joao Mario, who has joined from Inter Milan, while skipper Mark Noble and Michail Antonio face late fitness tests to see if they are able to return.
Meanwhile, Palace head to the London Stadium knowing that a win would take them above their opponents in the table and further boost their chances of Premier League survival.
Roy Hodgson is boosted by the news that Mamadou Sakho, Joel Ward and Yohan Cabaye are ready to return from injury. The Eagles are though still missing Ruben Loftus-Cheek, Jeffrey Schlupp and Scott Dann.
Palace, who came back to snatch a point in a 2-2 draw in the reverse fixture in October, will not be able to call on new signings Erdal Rakip and Jaroslaw Jach, but they could feature against Newcastle at the weekend.
Uwe Rosler was sacked by Fleetwood following a 3-0 reverse at Doncaster which condemned Town to a seventh straight defeat in all competitions.
Cambridge interim head coach Joe Dunne was pleased with how his side adapted to beat Grimsby 3-1.
Southend manager Chris Powell led the applause for Jason Demetriou after the right-back scored twice in the 3-1 win against Portsmouth at Roots Hall.
Morecambe boss Jim Bentley was the happier manager after Gregg Wylde's 90th-minute strike earned his side a point in their 1-1 draw with Forest Green.
Manager Gareth Ainsworth described Wycombe's 2-0 win at Cheltenham as a thoroughly professional performance.
Skipper Richard Wood scored the winner just before half time as in-form Rotherham pulled off a 1-0 victory at League One leaders Shrewsbury.